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A man in a lab coat is carefully mixing a blue liquid in a laboratory setting.

Research & Innovation

Core Areas

OUR TEAMS HARNESS ADVANCED CAPABILITIES IN:

SCIENTIFIC

  • Cell death signalling and CNS receptor modulation
  • Immuno-oncology
  • In vivo pharmacology and PK/PD analysis
  • Bioinformatics and computational chemistry
  • Protein engineering and molecular biology

INDUSTRY

  • Process optimization to prepare high-quality recombinant proteins
  • Protein development and bioprocessing
  • Developing a scalable process of biologics production

PRECLINICAL

  • In vivo efficacy studies in relevant disease models
  • Integrated DMPK and ADME characterisation
  • Non-GLP and GLP toxicology, including safety pharmacology
  • Development and validation of fit-for-purpose bioanalytical and biomarker assays
  • PK/PD and exposure–response modelling, preparation of IND/IMPD dossiers and study protocols

We integrate cutting-edge discovery platforms with a collaborative mindset to deliver tomorrow’s therapies

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Technologies

Core Competencies

At Adamed Discovery, we apply deep domain
expertise and advanced technologies to develop
novel therapeutics in oncology and CNS.
Our integrated capabilities span the entire
early drug discovery and preclinical development
pipeline — enabling us to generate and progress
high-value, first-in-class assets.

Competencies

01/08
Biotechnology & Protein Engineering
We specialize in the design, expression, and purification
of recombinant proteins, including fusion constructs
and complex biologics.

TECHNIQUES
Vector design, bacterial and mammalian expression systems, affinity and size-exclusion chromatography

APPLICATION
Production of functional proteins for screening, optimization, and preclinical testing

02/08
In Vitro Pharmacology
Our in vitro platforms enable mechanism-of-action studies,
potency profiling, and biomarker development.

TECHNIQUES
Cell-based assays, apoptosis/cytotoxicity analysis, gene expression modulation, imaging and localization studies

APPLICATION
Early-stage biological validation of therapeutic candidates

03/08
In Vivo Pharmacology
We conduct in vivo studies in translational models to
evaluate therapeutic efficacy, safety, and pharmacokinetics.

TECHNIQUES
Rodent models of solid tumors, neuroinflammation, ischemic injury; PK/PD analysis; histopathology

APPLICATION
Preclinical validation and candidate selection

04/08
Upstream & Downstream Processing
Our bioprocessing team supports scale-up and
optimization of biologics for IND-enabling studies.

TECHNIQUES
Bioreactor-based protein expression, ultrafiltration, polishing steps

APPLICATION
Development of robust, scalable production workflows

05/08
Bioinformatics & Cheminformatics
We integrate computational tools to support rational drug design,
target discovery, and data-driven decision making.

TECHNIQUES
Structure-based modeling, ligand docking, multi-omics analysis, competitor landscape profiling

APPLICATION
Acceleration of hit-to-lead workflows and mechanism discovery

06/08
Preclinical Development & Regulatory Support
We provide full IND-track capabilities with in-house and partner
expertise in regulatory science.

TECHNIQUES
GLP toxicology, ADME studies, regulatory documentation, Scientific Advice support, project and risk management

APPLICATION
Translation of validated candidates into clinical development

07/08
CNS-Focused Drug Discovery
Our specialized CNS team combines pharmacology and disease
biology to address unmet needs in neuropsychiatry and
neuroinflammation.

TECHNIQUES
Receptor profiling, behavior-based models, BBB permeability studies, cytokine panels

APPLICATION
Development of CNS-targeted therapeutics with high translational value

08/08
Business–Science Interface
We ensure scientific rigor is paired with strategic alignment, supporting co-development and in-licensing opportunities.
These capabilities enable Adamed Discovery to operate as a fully integrated discovery engine, advancing innovation from concept to clinic.